2021
1. Comparative sensitivity of proliferative and differentiated intestinal epithelial cells to the food contaminant, deoxynivalenol
S. Luo, Ch. Terciolo, M. Neves, S. Puel, Cl. Naylies, Y. Lippi, Ph. Pinton, I.P. Oswald. Environ. Pollut. 277, 116818 (2021). → doi: 10.1016/j.envpol.2021.116818
2. Human induced pluripotent stem cells (BIONi010-C) generate tight cell monolayers with blood-brain barrier traits and functional expression of large neutral amino acid transporter 1 (SLC7A5)
C. Goldeman, M. Andersen, A. Al-Robai, T. Buchholtz, N. Svane, B. Ozgür, B. Holst, E. Shusta, V. Hall, L. Saaby, P. Hyttel, B. Brodin, Eur. J. Pharm. Sci. 156, 105577 (2021). → doi: 10.1016/j.ejps.2020.105577
3. The effect of ultrasound cavitation on endothelial cells
M.S. Karthikesh, X. Yang. Exp. Biol. Med. XX, YY (2021). → doi: 10.1177/1535370220982301
4. Towards the development of a human in vitro model of the blood–brain barrier for virus-associated acute encephalopathy: assessment of the time- and concentration-dependent effects of TNF-a on paracellular tightness
H. Maeda, K. Hashimoto, H. Go, K. Miyazaki, M. Sato, Y. Kawasaki, N. Momoi, M. Hosoya. Exp. Brain Res. 239, 451 (2021). → doi: 10.1007/s00221-020-05985-7
5. Generation and Characterization of Immortalized Mouse Cortical Astrocytes From Wildtype and Connexin43 Knockout Mice
A. Cibelli, S.V. Lopez-Quintero, S. McCutcheon, E. Scemes, D.C. Spray, R.F. Stout Jr., S.O. Suadicani, M.M. Thi, M. Urban-Maldonado Front. Cell. Neurosci. 15, 647109 (2021). → doi: 10.3389/fncel.2021.647109
6. Lecithin coating as universal stabilization and functionalization strategy for nanosized drug carriers to overcome the blood–brain barrier
A.Wünsch, D.Mulac, K.Langer. Int. J. Pharm. 593, 120146 (2021). → doi: 10.1016/j.ijpharm.2020.120146
7. AMP-activated protein kinase is a key regulator of acute neurovascular permeability
S. Dragoni, B. Caridi, E. Karatsai, T. Burgoyne, M.H. Sarker, P. Turowski. J. Cell Sci. XX, YY (2021). → doi: 10.1242/jcs.253179
8. Tight junctions in the blood–brain barrier promote edema formation and infarct size in stroke – Ambivalent effects of sealing proteins
L. Winkler, R. Blasig, O. Breitkreuz-Korff, Ph. Berndt, S. Dithmer, H.C. Helms, D. Puchkov, K. Devraj, M. Kaya, Z. Qin, S. Liebner, H. Wolburg, A.V. Andjelkovic, A. Rex, I.E. Blasig, R.F. Haseloff, J. Cereb. Blood Flow Metab. 41, 132 (2021). → doi: 10.1177/0271678X20904687
9. Meprin ß: A novel regulator of blood–brain barrier integrity
M. Gindorf, S.E. Storck, A. Ohler, F. Scharfenberg, Ch. Becker-Pauly, C.U. Pietrzik, J. Cereb. Blood Flow Metab. 41, 31 (2021). → doi: 10.1177/0271678X20905206
10. Macrophage-mediated vascular permeability via VLA4/VCAM1 pathway dictates ascites development in ovarian cancer
S. Zhang, B. Xie, L. Wang, H. Yang, H. Zhang, Y. Chen, F. Wang, Ch. Liu, H. He, J. Clin. Invest. 131, e140315 (2021). → doi: 10.1172/JCI140315
11. Development of an In Vitro Airway Epithelial–Endothelial Cell Culture Model on a Flexible Porous Poly(Trimethylene Carbonate) Membrane Based on Calu-3 Airway Epithelial Cells and Lung Microvascular Endothelial Cells
T. Pasman, D. Baptista, S. van Riet, R.K. Truckenmüller, P.S. Hiemstra, R.J. Rottier, N.M. Hamelmann, J.M.J. Paulusse, D. Stamatialis, Á.A. Poot Membranes 11, 197 (2021). → doi: 10.3390/membranes11030197
12. Capabilities of selenoneine to cross the in vitro blood–brain barrier model
E. Drobyshev, S. Raschke, R.A. Glabonjat, J. Bornhorst, F. Ebert, D. Kuehnelt, T. Schwerdtle. Metallomics 13, mfaa007 (2021). → doi: 10.1093/mtomcs/mfaa007
13. TGF-ß1 increases permeability of ciliated airway epithelia via redistribution of claudin 3 from tight junction into cell nuclei
C. Schilpp, R. Lochbaum, P. Braubach, D. Jonigk, M. Frick, P. Dietl, O.H. Wittekindt. Pfluegers Arch. 473, 287 (2021). → doi: 10.1007/s00424-020-02501-2
14. SZR-104, a Novel Kynurenic Acid Analogue with High Permeability through the Blood–Brain Barrier
K. Molnár, B. Lorinczi, C. Fazakas, I. Szatmári, F. Fülöp, N. Kmetykó, R. Berkecz, I. Ilisz, I.A. Krizbai, I. Wilhelm,L. Vécsei. Pharmaceutics 13, 61 (2021). → doi: 10.3390/pharmaceutics13010061
15. Endothelial Iron Homeostasis Regulates Blood-Brain Barrier Integrity via the HIF2a—Ve-Cadherin Pathway
D. Rand, O. Ravid, D. Atrakchi, H. Israelov, Y. Bresler, Ch. Shemesh, L. Omesi, S. Liraz-Zaltsman, F. Gosselet, T.S. Maskrey, M. Schnaider Beeri, P. Wipf, I. Cooper Pharmaceutics 13, 311 (2021). → doi: 10.3390/pharmaceutics13030311
16. Astrocyte-derived Wnt growth factors are required for endothelial blood-brain barrier maintenance
S. Guerit, E. Fidan, J. Macas, C.J. CCzupalla, R. Figueiredo, A. Vijikumar, B.H. Yalcin, S. Thom, P. Winter, H. Gerhardt, K. Devraj, S. Liebner. Prog. Neurobiol. 199, 101937 (2021). → doi: 10.1016/j.pneurobio.2020.101937
17. Role of the C5a-C5a receptor axis in the inflammatory responses of the lungs after experimental polytrauma and hemorrhagic shock
S. Chakraborty, V.E. Winkelmann, S. Braumüller, A. Palmer, A. Schultze, B. Klohs, A. Ignatius, A. Vater, M. Fauler, M. Frick, M. Huber-Lang. Sci. Rep. 11, 2158 (2021). → doi: 10.1038/s41598-020-79607-1
18. Pharmacological targeting of host chaperones protects from pertussis toxin in vitro and in vivo
K. Ernst, A.-K. Mittler, V. Winkelmann, C. Kling, N. Eberhardt, A. Anastasia, M. Sonnabend, R. Lochbaum, J. Wirsching, M. Sakari, A.T. Pulliainen, C. Skerry, N.H. Carbonetti, M. Frick, H. Barth. Sci. Rep. 11, 5429 (2021). → doi: 10.1038/s41598-021-84817-2
19. Repeated exposure of Caco-2 versus Caco-2/HT29-MTX intestinal cell models to (nano)silver in vitro: Comparison of two commercially available colloidal silver products
20. K. Gillois, Ch. Stoffels, M. Leveque, I. Fourquaux, J. Blesson, V. Mils, S. Cambier, J. Vignard, H. Terrisse, G. Mirey, J.-N. Audinot, V. Theodorou, M.-H. Ropers, H. Robert, M. Mercier-Bonin. Sci. Total Environ. 754, 14232 (2021). → doi: 10.1016/j.scitotenv.2020.142324
21. Microfluidic In Vitro Platform for (Nano)Safety and (Nano)Drug Efficiency Screening
Y. Kohl, M. Biehl, S. Spring, M. Hesler, V. Ogourtsov, M. Todorovic, J. Owen, E. Elje, K. Kopecka, O.H. Moriones, N.G. Bastús, P. Simon, T. Dubaj, E. Rundén-Pran, V. Puntes, N. William, H. von Briesen, S. Wagner, N. Kapur, E. Mariussen, A. Nelson, A. Gabelova, M. Dusinska, Th. Velten, Th. Knoll. Small XX, YY (2021). → doi: 10.1002/smll.202006012
22. Human Astroviruses: A Tale of Two Strains
V. Hargest, A.E. Davis, S. Tan, V. Cortez, S. Schultz-Cherry. Viruses 13, 376 (2021). → doi: 10.3390/v13030376
2020
1. Genomic and phenotypic stability of Lactobacillus rhamnosus GG in an industrial production process
M. Stage, A. Wichmann Gustafsson, M. Jørgensen, N.I. Vera-Jimenéz, M. Wielje, D.S. Nielsen, A. Sandelin, Y. Chen, A. Baker
Appl. Environ. Microbiol. XX, YY (2020). → doi: 10.1128/AEM.02780-19
2. Retinoic acid signalling adjusts tight junction permeability in response to air-liquid interface conditions
R. Lochbaum, C. Schilpp, L. Nonnenmacher, M. Frick, P. Dietl, O.H. Wittekindt
Cell. Signalling 65, 1094213 (2020). → doi: 10.1016/j.cellsig.2019.109421
3. Synthesis and in vitro evaluation of cyclodextrin hyaluronic acid conjugates as a new candidate for intestinal drug carrier for steroid hormones
M. Heslera, D.H.Schwarz, S. Dähnhardt-Pfeiffer, S. Wagner, H. von Briesen, G. Wenz, Y. Kohl
Eur. J. Pharm. Sci. 143, 105181 (2020). → doi: 10.1016/j.ejps.2019.105181
4. Serine proteases as luminal mediators of intestinal barrier dysfunction and symptom severity in IBS
S. Edogawa, A. Ledwinson, S.A. Peters, L.L. Chikkamenahalli, W. Sundt, S. Graves, S.V. Gurunathan, M. Breen-Lyles, S. Johnson, R. Dyer, R. Graham, J. Chen, P. Kashyap, G. Farrugia, M. Grover. Gut 69, 62 (2020). → doi: 10.1136/gutjnl-2018-317416
5. TGR5-dependent hepatoprotection through the regulation of biliary epithelium barrier function
G. Merlen, N. Kahale, J. Ursic-Bedoya, V. Bidault-Jourdainne, H. Simerabet, I. Doignon, Z. Tanfin, I. Garcin, N. Péan, J. Gautherot, A. Davit-Spraul, C. Guettier, L. Humbert, D. Rainteau, K. Ebnet, Ch. Ullmer, D. Cassio, T. Tordjmann. Gut 69, 146 (2020). → doi: 10.1136/gutjnl-2018-31697
6. Enteropathogenic Escherichia coli (EPEC) Recruitment of PAR Polarity Protein Atypical PKC? to Pedestals and Cell–Cell Contacts Precedes Disruption of Tight Junctions in Intestinal Epithelial Cells
R. Tapia, S.E. Kralicek, G.A. Hecht Int. J. Mol. Sci. 21, 527 (2020). → doi: 10.3390/ijms21020527
7. Meprin ß: A novel regulator of blood–brain barrier integrity
M. Gindorf, S.E. Storck, A. Ohler, F. Scharfenberg, Ch. Becker-Pauly, C.U. Pietrzik, J. Cereb. Blood Flow Metab. XX, YY (2020). → doi: 10.1177/0271678X20905206
8. Tight junctions in the blood–brain barrier promote edema formation and infarct size in stroke – Ambivalent effects of sealing proteins
L. Winkler, R. Blasig, O. Breitkreuz-Korff, Ph. Berndt, S. Dithmer, H.C. Helms, D. Puchkov, K. Devraj, M. Kaya, Z. Qin, S. Liebner, H. Wolburg, A.V. Andjelkovic, A. Rex, I.E. Blasig, R.F. Haseloff, J. Cereb. Blood Flow Metab. XX, YY (2020). → doi: 10.1177/0271678X20904687
9. Identification of Parthenolide Dimers as Activators of Pyruvate Kinase M2 in Xenografts of Glioblastoma Multiforme in Vivo
Y. Ding, Q. Xue, S. Liu, K. Hu, D. Wang, T. Wang, Y. Li, H. Guo, X. Hao, W. Ge, Y. Zhang, A. Li J. Li, Y. Chen, Q. Zhang, J. Med. Chem. XX, YY (2020). → doi: 10.1021/acs.jmedchem.9b01328
10. Monophosphoryl Lipid a Attenuates Multiorgan Dysfunction During Post-Burn Pseudomonas Aeruginosa Pneumonia in Sheep
S. Fukuda, K. Ihara, J.K. Bohannon, A. Hernandez, N.K. Patil, L. Luan, C. Stothers, R. Stark, D.S. Prough, D.N. Herndon, E.R. Sherwood, P. Enkhbaatar, Shock 53, 307 (2020). → doi: 10.1097/SHK.0000000000001364
11. Claudin-12 deficiency causes nerve barrier breakdown, mechanical hypersensitivity and painfulness in polyneuropathy
J.T.-C. Chen, X. Hu, K. Doppler, O. Breitkreuz-Korff, I.U.C. Otto, J. Schwabe, A.-K. Reinhold, D. Günzel, S. Dithmer, M.K. Hankir, P. Fallier-Becker, L. Winkler, R. Blasig, C. Sommer, A. Brack, I.E. Blasig, H.L. Rittner. XX, YY (2020). → doi: 10.1101/768267
2019
1. Enhanced Bioavailability by Orally Administered Sirolimus Nanocrystals
J. Kong, K. Wu, Y. Ji, K. Chen, J. Zhang, H. Sun, Y. Liang, W. Liang, Y. Chang, J. Cheng, J. Tong, J. Li, G. Xing, G. Chen. ACS Appl. Bio Mater. 2, 4612 (2019). → doi: 10.1021/acsabm.9b00695
2. Effect of E Cigarette Emissions on Tracheal Cells Monitored at the Air–Liquid Interface Using an Organic Electrochemical Transistor
M.P. Ferro, L. Leclerc, M. Sleiman, B. Marchiori, J. Pourchez, R.M. Owens, M. Ramuz
Adv. Biosys. 3, 1800249 (2019). → doi: 10.1002/adbi.201800249
3. Oxidative Stress Increases Endogenous Complement-Dependent Inflammatory and Angiogenic Responses in Retinal Pigment Epithelial Cells Independently of Exogenous Complement Sources
T.-O. Trakkides, N. Schäfer, M. Reichenthaler, K. Kühn, R.J.M.G.E. Brandwijk, E.J.M. Toonen, F. Urban, J. Wegener, V. Enzmann, D. Pauly
Antioxidants 8, 548 (2019). → doi: 10.3390/antiox8110548
4. Non-pooled Human Platelet Lysate: A Potential Serum Alternative for In Vitro Cell Culture
M. Hesler, Y. Kohl, S. Wagner, H. von Briesen
ATLA, Altern. Lab. Anim. 47, 116 (2019). → doi: 10.1177/0261192919882516
5. Differential modulation of transendothelial electrical resistance by TRPV4 agonists is mediated by apoptosis and/or necrosis
N. Pairet , S. Mang, T. Kiechle, N. Laufhäger, P. Dietl, D.J. Lamb
Biochem. Biophys. Rep. 20, 100672 (2019). → doi: 10.1016/j.bbrep.2019.100672
6. Targeting claudin-4 enhances chemosensitivity of pancreatic ductal carcinomas
T. Sasaki, R. Fujiwara-Tani, S. Kishi, S. Mori, Y. Luo, H. Ohmori, I. Kawahara, K. Goto, Y. Nishiguchi, T. Mori, M. Sho, M. Kondo, H. Kuniyasu
Cancer Med. 8, 6700 (2019). → doi: 10.1002/cam4.2547
7. Toll-like receptor 3-mediated inflammation by p38 is enhanced by endothelial nitric oxide synthase knockdown
S.R. Koch, H. Choi, E.H. Mace, R.J. Stark
Cell Commun. Signaling 17, 33 (2019). → doi: 10.1186/s12964-019-0345-3
8. Stimulation of the A2B Adenosine Receptor Subtype Enhances Connexin26 Hemichannel Activity in Small Airway Epithelial Cells
A. Dierksa, A. Badera, T. Lehricha, A. Ngezahayo
Cell. Physiol. Biochem. 53, 606 (2019). → doi: 10.33594/000000160
9. Endothelial tight junctions and their regulatory signaling pathway
X. Cong, W. Kong
Cell. Signalling 66, 109485 (2019). → doi: 10.1016/j.cellsig.2019.109485
10. Syncytiotrophoblast of Placentae from Women with Zika Virus Infection Has Altered Tight Junction Protein Expression and Increased Paracellular Permeability
J. Miranda, D. Martín-Tapia, Y. Valdespino-Vázquez, L. Alarcón, A. Espejel-Nuñez, M. Guzmán-Huerta, J.E. Muñoz-Medina, M. Shibayama, B. Chávez-Munguía, G. Estrada-Gutiérrez, S. Lievano, J.E. Ludert, L. González-Mariscal
Cells 8, 1174 (2019). → doi: 10.3390/cells8101174
11. Transient blood–brain barrier disruption isinduced by low pulsed electrical fields in vitro: ananalysis of permeability and trans-endothelialelectric resistivity
S. Sharabi, Y. Bresler, O. Ravid, Ch. Shemesh, D. Atrakchi, M. Schnaider-Beeri, F. Gosselet, L. Dehouck, D. Last, D. Guez, D. Daniels, Y. Mardor, I. Cooper
Drug Delivery 26, 459 (2019). → doi: 10.1080/10717544.2019.1571123
12. In vitro and in vivo effects of a mycotoxin, deoxynivalenol, and a trace metal, cadmium, alone or in a mixture on the intestinal barrier
S. Luo, Ch. Terciolo, A.P.F.L. Bracarense, D. Payros, Ph. Pinton, I.P. Oswald
Environ. Int. 132, 105082 (2019). → doi: 10.1016/j.envint.2019.105082
13. A unified in vitro test system for the assessment of tight junction modulators
D. Saaber, S. Reichl
Eur. J. Pharm. Biopharm. 142, 353 (2019). → doi: 10.1016/j.ejpb.2019.07.004
14. The impact of gastrointestinal mucus on nanoparticle penetration – in vitro evaluation of mucus-penetrating nanoparticles for photodynamic therapy
L. Mahlert, J. Anderski, D. Mulac, K. Langer
Eur. J. Pharm. Sci. 133, 28 (2019). → doi: 10.1016/j.ejps.2019.03.010
15. Revisiting an old antibiotic: bacitracin neutralizes binary bacterial toxins and protects cells from intoxication
L. Schnell, I. Felix, B. Müller, M. Sadi, F. von Bank, P. Papatheodorou, M.R. Popoff, K. Aktories, E. Waltenberger, R. Benz, C. Weichbrodt, M. Fauler, M. Frick, H. Barth
FASEB J. 33, 5755 (2019). → doi: 10.1096/fj.201802453R
16. Impedance Spectroscopy as a Tool for Monitoring Performance in 3D Models of Epithelial Tissues
T. Gerasimenko, S. Nikulin, G. Zakharova, A. Poloznikov, V. Petrov, A. Baranova, A. Tonevitsky
Front. Bioeng. Biotechnol. 7, 474 (2019). → doi: 10.3389/fbioe.2019.00474
17. PECAM-1 Stabilizes Blood-Brain Barrier Integrity and Favors Paracellular T-Cell Diapedesis Across the Blood-Brain Barrier During Neuroinflammation
I. Wimmer, S. Tietz, H. Nishihara, U. Deutsch, F. Sallusto, F. Gosselet, R. Lyck, W.A. Muller, H. Lassmann, B. Engelhardt
Front. Immunol. 10, 711 (2019). → doi: 10.3389/fimmu.2019.00711
18. Autophagy Protects the Blood-Brain Barrier Through Regulating the Dynamic of Claudin-5 in Short-Term Starvation
Z. Yang, Ch. Huang, Y. Wu, B. Chen, W. Zhang, J. Zhang
Front. Physiol. 10, 2 (2019). → doi: 10.3389/fphys.2019.00002
19. Structure and biological activities of a hexosamine-rich cell wall polysaccharide isolated from the probiotic Lactobacillus farciminis
E. Maes, I. Sadovskaya, M. Lévêque, E. Elass-Rochard, B. Payré, Th. Grard, V. Théodorou, Y. Guérardel, M. Mercier-Bonin
Glycoconjugate J. 36, 39 (2019). → doi: 10.1007/s10719-018-09854-y
20. IL-13 Impairs Tight Junctions in Airway Epithelia
H. Schmidt, P. Braubach, C. Schilpp, R. Lochbaum, K. Neuland, K. Thompson, D. Jonigk, M. Frick, P. Dietl, O.H. Wittekindt
Int. J. Mol. Sci. 20, 3222 (2019). → doi: 10.3390/ijms20133222
21. Temporal Effects of Quercetin on Tight Junction Barrier Properties and Claudin Expression and Localization in MDCK II Cells
E. Gamero-Estevez, S. Andonian, B. Jean-Claude, I. Gupta, A.K. Ryan
Int. J. Mol. Sci. 20, 4889 (2019). → doi: 10.3390/ijms20194889
22. The Influence of Capsaicin on the Integrity of Microvascular Endothelial Cell Monolayers
M. Kaiser, M. Burek, S. Britz, F. Lankamp, S. Ketelhut, B. Kemper, C. Förster, Ch. Gorzelanny, F.M. Goycoolea
Int. J. Mol. Sci. 20, 122 (2019). → doi: 10.3390/ijms20010122
23. Controversial roles for dexamethasone in glioblastoma – Opportunities for novel vascular targeting therapies
D. Dubinski, E. Hattingen, Ch. Senft, V. Seifert, K.G. Peters, Y. Reiss, K. Devraj, K.H. Plate
J. Cereb. Blood Flow Metab. 39, 1460 (2019). → doi: 10.1177/0271678X19859847
24. Short communication: Processed bovine colostrum milk protein concentrate increases epithelial barrier integrity of Caco-2 cell layers
R.C. Anderson, J.E. Dalziel, N.W. Haggarty, K.E. Dunstan, P.K. Gopal, N.C. Roy
J. Dairy Sci. 102, 10772 (2019). → doi: 10.3168/jds.2019-16951
25. Impact of Docetaxel on blood-brain barrier function and formation of breast cancer brain metastases
S. Bernatz, E.I. Ilina, K. Devraj, P.N. Harter, K. Mueller, S. Kleber, Y. Braun, C. Penski, Ch. Renner, R. Halder, L. Jennewein, Ch. Solbach, F. Thorsen, B.C. Pestalozzi, A. Mischo, M. Mittelbronn
J. Exp. Clin. Cancer Res. 38, 434 (2019). → doi: 10.1186/s13046-019-1427-1
26. Fucosyltransferase 4 and 7 mediates adhesion of non-small cell lung cancer cells to brain-derived endothelial cells and results in modification of the blood–brain-barrier: in vitro investigation of CD15 and CD15s in lung-to-brain metastasis
S.A. Jassam, Z. Maherally, K. Ashkan, G.J. Pilkington, H.L. Fillmore
J. Neuro-Oncol. 143, 405 (2019). → doi: 0.1007/s11060-019-03188-x
27. Haem iron reshapes colonic luminal environment: impact on mucosal homeostasis and microbiome through aldehyde formation
O.C.B. Martin, M. Olier, S. Ellero-Simatos, N. Naud, J. Dupuy, L. Huc, S. Taché, V. Graillot, M. Levêque, V. Bézirard, C. Héliès-Toussaint, F.B.Y. Estrada, V. Tondereau, Y. Lippi, C. Naylies, L. Peyriga, C. Canlet, A.M. Davila, F. Blachier, L. Ferrier, E. Boutet-Robinet, F. Guéraud, V. Théodorou, F.H.F. Pierre
Microbiome 7, 72 (2019). → doi: 10.1186/s40168-019-0685-7
28. Improved Drug Delivery to Brain Metastases by Peptide-Mediated Permeabilization of the Blood–Brain Barrier
S.N. Aasen, H. Espedal, Ch.F. Holte, O. Keunen, T.V. Karlsen, O. Tenstad, Z. Maherally, H. Miletic, T. Hoang, A.V. Eikeland, H. Baghirov, D.E. Olberg, G.J. Pilkington, G. Sarkar, R.B. Jenkins, T. Sundstrøm, R. Bjerkvig, F. Thorsen
Mol. Cancer Ther. 18, 2171 (2019). → doi: 10.1158/1535-7163.MCT-19-0160
29. LRP1 Has a Predominant Role in Production over Clearance of Aß in a Mouse Model of Alzheimer’s Disease
B. Van Gool, S.E. Storck, S.M. Reekmans, B. Lechat, Ph.L.S.M. Gordts, L. Pradier, C.U. Pietrzik, A.J.M. Roebroek
Mol. Neurobiol. 56, 7234 (2019). → doi: 10.1007/s12035-019-1594-2
30. Side-directed Transfer and Presystemic Metabolism of Selenoneine in a Human Intestinal Barrier Model
I. Rohn, N. Kroepfl, J. Bornhorst, D. Kuehnelt, T. Schwerdtle
Mol. Nutr. Food Res. 63, 1900080 (2019). → doi: 10.1002/mnfr.201900080
31. Polyphenol Extracts from Three Colombian Passifloras (Passion Fruits) Prevent Inflammation-Induced Barrier Dysfunction of Caco-2 Cells
J.C. Carmona-Hernandez, G. Taborda-Ocampo, J.C. Valdez, B.W. Bolling, C.H. González-Correa
Molecules 24, 4614 (2019). → doi: 10.3390/molecules24244614
32. Dietary tryptophan links encephalogenicity of autoreactive T cells with gut microbial ecology
J.K. Sonner, M. Keil, M. Falk-Paulsen, N. Mishra, A. Rehman, M. Kramer, K. Deumelandt, J. Röwe, K. Sanghvi, L. Wolf, A. von Landenberg, H. Wolff, R. Bharti, I. Oezen, T.V. Lanz, F. Wanke, Y. Tang, I. Brandao, S.R. Mohapatra, L. Epping, A. Grill, R. Röth, B. Niesler, S.G. Meuth, Ch.A. Opitz, J.G. Okun Ch. Reinhardt, F.C. Kurschus, W. Wick, H.B. Bode, Ph. Rosenstiel, M. Platten
Nat. Commun. 10, 4877 (2019). → doi: 10.1038/s41467-019-12776-4
33. Crossing the blood-brain-barrier with nanoligand drug carriers self-assembled from a phage display peptide
L.-P. Wu, D. Ahmadvand, J. Su, A. Hall, X. Tan, Z.S. Farhangrazi, S.M. Moghimi
Nat. Commun. 10, 4635 (2019). → doi: 10.1038/s41467-019-12554-2
34. Targeting claudin-4 enhances CDDP-chemosensitivity in gastric cancer
Y. Nishiguchi, R. Fujiwara-Tani, T. Sasaki, Y. Luo, H. Ohmori, S. Kishi, S. Mori, K. Goto, W. Yasui, M. Sho, H. Kuniyasu
Oncotarget 10, 2189 (2019). → doi: 10.18632/oncotarget.26758
35. Corticosteroid signaling at the brain-immune interface impedes coping with severe psychological stress
A. Kertser, K. Baruch, A. Deczkowska, A. Weiner, T. Croese, M. Kenigsbuch, I. Cooper, M. Tsoory, S. Ben-Hamo, I. Amit, M. Schwartz
Sci. Adv. 5, eaav4111 (2019). → doi: 10.1126/sciadv.aav4111
36. Claudin-3-deficient C57BL/6J mice display intact brain barriers
M.C. Dias, C. Coisne, I. Lazarevic, P. Baden, M. Hata, N. Iwamoto, D.M.F. Francisco, M. Vanlandewijck, L. He, F.A. Baier, D. Stroka, R. Bruggmann, R. Lyck, G. Enzmann, U. Deutsch, Ch. Betsholtz, M. Furuse, S. Tsukita & B. Engelhardt
Sci. Rep. 9, 203 (2019). → doi: 10.1038/s41598-018-36731-3
37. Unraveling In Vivo Brain Transport of Protein-Coated Fluorescent Nanodiamonds
P. Moscariello, M. Raabe, W. Liu, S. Bernhardt, H. Qi, U. Kaiser, Y. Wu, T. Weil, H.J. Luhmann, J. Hedrich
Small 15, 1902992 (2019). → doi: 10.1002/smll.201902992
38. The Antibiotic Bacitracin Protects Human Intestinal Epithelial Cells and Stem Cell-Derived Intestinal Organoids from Clostridium difficile Toxin TcdB
Z. Zhu, L. Schnell, B. Müller, M. Müller, P. Papatheodorou, H. Barth
Stem Cells Int. 2019, 4149762 (2019). → doi: 10.1155/2019/4149762
39. Multi-endpoint toxicological assessment of polystyrene nano- and microparticles in different biological models in vitro
M. Heslera, L. Aengenheister, B. Ellinger, R. Drexel, S. Straskraba, C. Jost, S. Wagner, F. Meier, H. von Briesen, C. Büchel, P. Wick, T. Buerki-Thurnherr, Y. Kohl
Toxicol. In Vitro 61, 104610 (2019). → doi: 10.1016/j.tiv.2019.104610
40. Modelling Macular Edema: The Effect of IL-6 and IL-6R Blockade on Human Blood–Retinal Barrier Integrity In Vitro
M. Mesquida, F. Drawnel, P.J. Lait, D.A. Copland, M.L. Stimpson, V. Lloren, M.S. de la Maza, A. Adan, G. Widmer, P. Strassburger, S. Fauser, A.D. Dick, R.W. J. Lee, B. Molins
Transl. Vis. Sci. Techn. 8, 32 (2019). → doi: 10.1167/tvst.8.5.32
2018
1. Brain Delivery of Multifunctional Dendrimer Protein Bioconjugates. Adv. Sci. (2018).
2. Importance of the IL-1 Axis in Haemophilus influenzae–stimulated M1 Macrophages Driving Transepithelial Signaling. Am. J. Respir. Cell Mol. Biol. (2018).
3. Effects of arsenolipids on in vitro blood-brain barrier model. Arch. Toxicol. (2018).
4. Reversible opening of the blood-brain barrier by claudin-5-binding variants of Clostridium perfringens enterotoxin's claudin-binding domain. Biomaterials. (2018).
5. HtrA1 Mediated Intracellular Effects on Tubulin Using a Polarized RPE Disease Model. EBioMedicine. (2018).
6. Real-time acquisition of transendothelial electrical resistance in an all-human, in vitro, 3-dimensional, blood–brain barrier model exemplifies tight-junction integrity. FASEB J. (2018)
7. Alteration of sphingolipid metabolism as a putative mechanism underlying LPS-induced BBB disruption. J. Neurochem. (2018).
8. A novel human induced pluripotent stem cell blood-brain barrier model: Applicability to study antibody-triggered receptor-mediated transcytosis. Sci. Rep. (2018).
9. Optimized procedures for generating an enhanced, near physiological 2D culture system from porcine intestinal organoids. Stem Cell Res. (2018).
10. Localized delivery of curcumin into brain with polysorbate 80-modified cerasomes by ultrasound-targeted microbubble destruction for improved Parkinson's disease therapy. Theranostics. (2018).
2017
1. Insights from mathematical modelling for T cell migration into the central nervous system. Math. Med. Biol. (2017)
2. Establishment of a method for evaluating endothelial cell injury by TNF-α in vitro for clarifying the pathophysiology of virus-associated acute encephalopathy. Pediatr. Res. (2017)
3. Development of Blood-Brain Barrier Permeable Nanoparticles as Potential Carriers for Salvianolic Acid B to CNS. Planta Med. (2017)
4. Establishment of a Human Blood-Brain Barrier Co-culture Model Mimicking the Neurovascular Unit Using Induced Pluri- and Multipotent Stem Cells. Stem Cell Rep. (2017)
5. Exfoliated graphene nanosheets: pH-sensitive drug carrier and anti-cancer activity. J. Colloid Interface Sci. (2017)
6. Endothelial Basement Membrane Laminin 511 Contributes to Endothelial Junctional Tightness and Thereby Inhibits Leukocyte Transmigration. Cell Rep. (2017)
7. Dual role of ALCAM in neuroinflammation and blood–brain barrier homeostasis. PNAS .(2017)
8. Gb3-binding lectins as potential carriers for transcellular drug delivery. Drug Delivery. (2017)
9. Early-lactation, but not mid-lactation, bovine lactoferrin preparation increases epithelial barrier integrity of Caco-2 cell layers. J. Dairy Sci. (2017)
10. Primary porcine brain endothelial cells as in vitro model to study effects of ultrasound on blood-brain barrier function. IEEE Trans. Sonics Ultrason. (2017)
