■  监测自由基在体内随时间的分布与药代动力学

■  与CT联用实现对自由基在颅骨表面的共定位

■  小鼠整体3D动态电子共振成像

向小鼠体内注射自旋探针后，仪器检测探针信号强度：探针先散布全身，随着时间推移在膀胱中聚集。每张三维图像成像间隔4.5 s，由225张投射图像组合而成。

图1  自旋探针在小鼠体内的 空间分布

■   肿瘤氧分压成像

裸鼠植入LNCap（人前列腺癌）12天后，注射自旋探针，整体检测氧分压。肿瘤病灶区域相比其他区域氧分压显著降低。三维图像成像间隔8 min，由8000张投射图像组合而成。

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3. Elas, M. "Martyna Elas, Martyna Krzykawska-Serda, Michał Gonet, Anna Kozińska, and Przemysław M. Płonka." Medical Imaging Methods: Recent Trends (2019): 1

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小动物自由基成像系统.pdf