ERI TM 600工作原理


向小动物体内注射含未成对电子的自旋探针,小鼠内的生理环境会影响自旋探针的波谱特性,当施加一个磁场时,仪器可检测未成对电子在外加磁场中的跃迁,进而获得探针在每个位置的含量,摄取及排出速率和转化速率等数据并构建图像。


专为活体动物所开发的样品池。

具备温度控制、换气和鼠脑固定装置。


高精度位移台控制装置,

保证测量位置的精确。




■  监测自由基在体内随时间的分布与药代动力学


■  与CT联用实现对自由基在颅骨表面的共定位


■  小鼠整体3D动态电子共振成像


向小鼠体内注射自旋探针后,仪器检测探针信号强度:探针先散布全身,随着时间推移在膀胱中聚集。每张三维图像成像间隔4.5 s,由225张投射图像组合而成。


图1  自旋探针在小鼠体内的

空间分布








■   肿瘤氧分压成像


裸鼠植入LNCap(人前列腺癌)12天后,注射自旋探针,整体检测氧分压。肿瘤病灶区域相比其他区域氧分压显著降低。三维图像成像间隔8 min,由8000张投射图像组合而成。



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3. Elas, M. "Martyna Elas, Martyna Krzykawska-Serda, Michał Gonet, Anna Kozińska, and Przemysław M. Płonka." Medical Imaging Methods: Recent Trends (2019): 1

4. Czechowski, T., et al. "Adaptive Modulation Amplitude in 2D Spectral-Spatial EPR Imaging." Acta Physica Polonica A 133.3 (2018): 710-712.

5. Penkala, Krzysztof, et al. "Graphene-based electrochemical biosensing system for medical diagnostics." 2017 IEEE 37th International Conference on Electronics and Nanotechnology (ELNANO). IEEE, 2017.

6. Chlewicki, Wojciech, et al. "Performance of image reconstrucion algorithms in electron paramagnetic resonance tomography with multiharmonic analysis." 2017 IEEE 37th International Conference on Electronics and Nanotechnology (ELNANO). IEEE, 2017.


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